What is Kaftrio? A Groundbreaking Therapy for Cystic Fibrosis Patients in the USA and Worldwide

Published: April 2025 | Author: Orphan Drug UK Medical Team

Cystic fibrosis (CF) is a serious, inherited condition that affects thousands of people worldwide, causing persistent respiratory infections and complications that worsen over time. Fortunately, scientific progress has brought about a revolutionary treatment: Kaftrio — a triple combination therapy developed by Vertex Pharmaceuticals. Known as Trikafta in the United States, this medication has drastically changed the quality of life for many CF patients.

But there’s more to the story — especially when it comes to access and affordability. In this article, we’ll explore how OrphanDrug.co.uk helps patients and healthcare providers obtain Kaftrio at significantly lower costs than those found in the US.

What is Kaftrio?

Kaftrio is a combination of three active substances: elexacaftor, tezacaftor, and ivacaftor. Together, they target the root cause of cystic fibrosis — the malfunctioning CFTR protein caused by mutations in the CFTR gene. Most notably, this therapy is designed for individuals who have at least one F508del mutation, which is present in around 90% of people with CF.

By correcting the folding, trafficking, and function of the CFTR protein, Kaftrio improves lung function, reduces pulmonary exacerbations, and enhances overall health.

How Does Kaftrio Work?

Each component of Kaftrio plays a distinct role:

  • Elexacaftor and tezacaftor work as correctors, helping the faulty CFTR protein reach the cell surface.
  • Ivacaftor acts as a potentiator, keeping the protein channels open longer to allow better movement of chloride and water.

This improved chloride transport leads to thinner mucus, easier breathing, and a reduction in lung infections.

Who is Eligible for Kaftrio?

Kaftrio is approved for patients aged 6 years and older who have at least one responsive mutation — primarily F508del — in the CFTR gene. It is taken in combination with Kalydeco (ivacaftor-only), typically in tablet form.

Common Pack Details

  • Kaftrio 75 mg/50 mg/100 mg film-coated tablets (56 tablets)
    Manufacturer: Vertex Pharmaceuticals (Germany) GmbH
    Active Ingredients: Ivacaftor, Tezacaftor, Elexacaftor

To learn more about Kaftrio and related treatments, visit:
Kaftrio Product Page

Kaftrio in the UK, EU & US – Pricing Differences

While Kaftrio has become a standard of care in many developed countries, its cost continues to be a major barrier — particularly in the United States, where prices often exceed $300,000 per year.

However, in the European Union, the same treatment is often available at a fraction of the US price. At OrphanDrug.co.uk, we work closely with EU-licensed suppliers and wholesalers to make this medication 3–4 times more affordable — without compromising on authenticity, safety, or quality.

✅ Why Choose OrphanDrug.co.uk?

  • Access to EU-Sourced Original Medications
  • Prices 3–4x Lower Than the US Market
  • Licensed Distributors Only
  • Secure Delivery to the UK, US, and Worldwide

We understand that timely access to effective treatment can be life-changing. That’s why we’re committed to helping patients — especially those facing financial or geographic barriers — obtain the therapies they need.

Frequently Asked Questions (FAQs)

Is Kaftrio the same as Trikafta?
Yes. Kaftrio is the European trade name for the same drug known as Trikafta in the US.

Do I need a prescription to order Kaftrio?
Yes. You must provide a valid prescription and confirm genetic eligibility before purchase.

Is OrphanDrug.co.uk a licensed supplier?
We partner only with EU-licensed wholesalers and distributors, ensuring full regulatory compliance and pharmaceutical-grade products.

Final Thoughts

Kaftrio is a transformative treatment that offers new hope for cystic fibrosis patients. But access shouldn’t be limited by geography or inflated pricing.

At OrphanDrug.co.uk, we’re proud to support families, clinics, and hospitals by offering this essential medicine at a price that reflects compassion — not just commerce.

Visit OrphanDrug.co.uk to request a quote or start your order today.